Document 0126
 DOCN  M9490126
 TI    [CT and MRT in progressive multifocal leukoencephalopathy (PML)]
 DT    9411
 AU    Lanfermann H; Heindel W; Schroder R; Lackner K; Institut und Poliklinik
       fur Radiologische Diagnostik,; Universitat zu Koln.
 SO    Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1994
       Jul;161(1):38-43. Unique Identifier : AIDSLINE MED/94318837
 AB    Radiological findings and course of progressive multifocal
       leukoencephalopathy in 14 patients (1 woman, 13 men; 13 HIV
       seropositive, 1 chronic lymphatic leukaemia) were analysed
       retrospectively and correlated with clinical symptoms. A total of 21 CT
       and 16 MRI studies were evaluated. CT scans and MR images of 9 patients,
       which had been obtained in less than two weeks, could be compared to
       each other. MRI was superior to CT: 6 lesions with a diameter of 1 cm
       and below were not detected on CT scans, in 5 patients the extent of
       lesions was underestimated. Cortical involvement, mass effect or signs
       of atrophy were missing. Only 1 of 67 lesions showed a tiny enhancement
       after Gd injection. Due to the pattern and spread of lesions, which
       showed a close correlation to the neurologic symptoms, three different
       types of PML are suggested: 1. initial precentral demyelinisation with
       contralateral hemiparesis (n = 8); 2. lesions in temporo-occipital
       locations with visual disturbances (n = 2); 3. predominantly bilateral
       lesions of cerebellar white matter with ataxia (n = 4).
 DE    Adult  Biopsy  Brain/PATHOLOGY  Comparative Study  English Abstract
       Female  Human  HIV Seropositivity/COMPLICATIONS  HIV-1/IMMUNOLOGY
       Leukemia, Lymphocytic, Chronic/COMPLICATIONS  Leukoencephalopathy,
       Progressive Multifocal/*DIAGNOSIS/  EPIDEMIOLOGY/ETIOLOGY  *Magnetic
       Resonance Imaging  Male  Middle Age  Retrospective Studies  Time Factors
       *Tomography, X-Ray Computed  JOURNAL ARTICLE

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